Excellent Research: Biofilms, SIBO and the Fibromyalgia What is The Connection?

2008 Dr. Rodney M. Donlan This 2008 scanning electron micrograph (SEM) depicts the lumen of a segment of a central venous catheter removed from an asymptomatic patient. The biofilm contained the rod-shaped bacteria, Alcaligenes xylosoxidans in association with fibrinlike material on the catheter’s surface.

This image accompanied the Emerging Infectious Diseases® journal article entitled, Alcaligenes xylosoxidans Bloodstream Infections in Outpatient Oncology Office”, by Moon J. Kim, Elizabeth Bancroft, Eleanor Lehnkering, Rodney M. Donlan, and Laurene Mascola. See a link to the article below. Alcaligenes xylosoxidans, also known as Achromobacter xylosoxidans, is a gram-negative, water-borne organism that causes healthcare-associated infections and bacteremia in immunocompromised patients with indwelling catheters; it can also contaminate liquids. A. xylosoxidans is found in soil and water and grows in saline.

Written By:The Restore Team

The image to the left is a bacterial biofilm. It is a slimy, impenetrable matrix that bacterial colonies create in order to protect themselves from our immune system.

It took a lot of research and trial and error to realize how important this was in ending my fibromyalgia.

As it turned out, once I began clearing this stuff out of my body, everything began to change for me. And quickly.

My name is Donna Griffin and I suffered for a very long time with fibromyalgia and other autoimmune conditions including IBS, CFS and ulcerative colitis.

It wasn’t until I began learning about biofilm and its role in these type of conditions that things began to dramatically shift.

What I’m about to share with you may not be something that works for everyone who suffers from fibromyalgia, but it sure has helped thousands.

I will spare you the story of my long, 15 year journey as I can imagine you may already understand how horrible it can be.

But during those sick years, I was doing my research. Lots of research.

I ventured down many avenues and took all the ones that showed any sort of promise.

Then I came across a research paper from Cedars Sinai Center in Los Angeles that showed a link between SIBO (small intestinal bacterial overgrowth) and fibromyalgia.

This study revealed that 100% of the people who had fibromyalgia also had SIBO [1]

Another recent study [2] found that out of 40 patients with fibromyalgia, 28 (70%) had intestinal permeability (i.e. leaky gut syndrome). And, incredibly, 12 of the 28 patients with leaky gut showed no gut symptoms.

That was shocking to me. Because almost half of those patients with leaky gut showed absolutely no digestive symptoms.

(Continue reading below to learn more about this study)

This one discovery led me down the path that eventually led me out of my nightmare.

You see, once I began focusing on my gut microbiome, where bacterial overgrowth was happening, everything starting changing for me. And fast!

And when I began connecting these dots, things really began to shift…

Here’s what happened:

SIBO, Biofilms and the Fibromyalgia Connection

I began learning ways to eliminate SIBO and quickly realized that the #1 reason that SIBO is so difficult to eliminate is because of biofilm.

As you learned earlier, biofilm is a protective layer that harmful gut bacteria, as well as Candida yeast, create to protect themselves from our immune system.

Did you know that over 80% of bacterial infections in humans are estimated to involve the formation of bacterial colonies, or biofilms.

It’s also been documented that bacteria protected within biofilms are up to 1,000 times more resistant to antibiotics than if they were free-floating.[3]

Worst of all, bacterial biofilm harbors over 40 different kinds of neurotoxins and cytokines, including ammonia, which are secreted by these pathogenic bacteria, causing all kinds of neurological damage, such as brain fog, inflammation and fatigue.

Fun Fact #1


And this is just the first problem with biofilms…

Once colonies of yeast & bacteria become overgrown beneath this biofilm, the toxins they secrete can often break down delicate links in the intestinal wall known as “tight junctions”, which are essentially the glue that keeps the intestinal wall together.

Established colonies are known to puncture through these tight junctions allowing organisms and other toxins and undigested food particles to enter the bloodstream.

Leaky Gut Syndrome

The result is something called “Leaky Gut Syndrome”.

Many believe this to be a key in understanding allergies, food sensitivities and why the body goes into an inflammatory response.

The immune system sees these “foreign invaders” entering the bloodstream and mounts an all-out attack.

The only problem is, this attack is continuous. Never ending. The gut is letting in these invaders indefinitely.

Your body is constantly “under attack”. In a continuous state of code red.

That’s when I made a breakthrough discovery…

I discovered an all-natural substance that proved to be a clear cut winner at breaking down biofilm.

In fact, our body naturally produces them for almost every biochemical process it goes through. These are enzymes.

There are so many different types of enzymes that the body produces, however, we’ve isolated a handful of enzymes which work extremely well at dissolving biofilm.

These exact enzymes have also long been used for their anti-aging, anti-inflammatory, anti-viral and blood cleansing properties for centuries.

These are all-natural, proteolytic enzymes which work quickly and effectively to break down the biofilm barrier in the gut to expose these harmful pathogens.

Once exposed, our immune system can go to work regulating these pathogens.

biofilm life cycle restore 3
How biofilm attacks the body

These natural enzymes went to work and quickly began breaking down years worth of biofilm strongholds within my gut.

I knew this because I actually felt worse before I felt better. I was “herxing” for the first few days. I felt very fatigued and my body wasn’t very happy.

This can sometimes happen when the body is tasked to process all the toxic material and dead bacteria that is moving out at a rapid rate. It often feels like the cold or flu.

biofilm disruption
How enzymes dissolve biofilm

However, I learned ahead of time that this may potentially happen and I saw it as a good sign that what I was doing was actually working.

It wasn’t until later that I refined my approach by following a specific diet and introducing specialized probiotics to my daily regimen.

The diet was there to help kill off any resilient pathogenic bacteria leftover and the specialized probiotics were used to replenish my gut microbiome with friendly colonies.

In the first couple of weeks I noticed a few improvements with my muscle fatigue. I seemed to have a little bit more energy and less joint pain.

With each passing week, I was getting stronger and stronger.

I was waking up feeling refreshed from a deep nights rest and my body felt lighter.

The way I describe it to people is that my body felt like a pair of glasses that were caked in mud and the mud had finally washed away revealing a clarity that I had long forgotten.

The strange thing about being chronically ill is that often, you don’t really realize how sick you actually were until you begin to feel better.

And wow did I feel better! I could barely contain my energy. I eventually began to have more energy than I knew what to do with.

It felt like I stepped into a new body. One that was 25 years younger.

Looking back now, it makes perfect sense.

Because, if our bodies are 10x more microbe cells than human cells, then it’s obvious that the focus should be on the microbiome and ensuring it’s in balance.

Modern medicine is beginning to recognize this as well and it is exactly why so much research in the past few years has been centered around the microbiome.

I had to share this discovery with others. I knew it would benefit so many who, like me, were trying to escape this living nightmare.

For the last 15 years, myself along with a few other former patients, have been perfecting and refining this program, which has already helped thousands get back the life they once had.

Here’s How it Works:

Essentially, there are 3 phases:

1. Dissolve/Disrupt the biofilm
2. Eliminate the pathogenic colonies and toxic buildup
3. Restore the gut microbiome with friendly bacterial colonies

I found it must be done in this order or else you’ll be perpetually stuck just trying to get past step 1.

The Restore 3 Program is a 3-Phase Program that:

Green-Check-Mark-3-21x19Supports Rapid Biofilm Disruption – So you can see real results fast.
Green-Check-Mark-3-21x19Clears Out Bacteria & Yeast Buildup – Feel better & have more energy.
Green-Check-Mark-3-21x19Step-by-Step Guide – Be guided through each step. Know exactly what to do.

Each part of the program was carefully designed according to what actually worked for us. There is no fluff here. It’s been refined down to only a few short steps that anyone can follow and see fast results.


Why Does Restore 3 Work?

Because each of these ingredients below revealed over and over again to be the clear-cut winners for us. Each ingredient was carefully selected to make this a powerful, all-in-one formula:

Discovery #1: Proteolytic Enzymes – Protease S & Serrapeptase

Dissolves pathogenic biofilms & fibrin. Cleanses the blood of debris & kills invading bacteria.

Often referred to as the super enzyme, Serrapeptase and Protease S are the true workhorses of the biofilm disrupting component of this formulation. Biofilm is mostly made up of protein and sugars. In order to breakdown the tough wall of biofilm, it requires a lot of protein digesting enzymes and Protease & Serrapeptase are among some of the most powerful enzymes currently used [7] . Any biofilm disrupting supplement should have a minimum of 150,000 HUT (Hemoglobin unit on a Tyrosine basis) of activity. We made sure to provide a minimum of 200,000 HUT for our formula.

Discovery #2: Magnesium Malate

Helps restore oxygen and energy to muscles & reduces muscle pain and tender points in fibromyalgia patients.

Researchers have found that people with fibromyalgia have decreased levels of oxygen in their muscles, also known as muscle hypoxia [8]. Biopsies of those muscles have shown muscle tissue breakdown, mitochondrial damage, and low levels of ATP, which may help explain the widespread muscle pain characteristic of fibromyalgia. Magnesium malate has been shown to help ease pain caused by muscle and tissue hypoxia because it helps the body to produce energy even under low oxygen or hypoxic conditions [9].

Discovery #3: Cellulase & Hemicellulase

Breaks down the polysaccharides of pathogenic biofilms. Converts sugars to energy.

No biofilm dissolving formula is complete without the use of cellulase and hemicellulase to support the break down of the polysaccharide element of biofilm. Polysaccharide are complex sugars that bind with protein molecules which actually make up most of the biofilm structure. If you don’t have these sugar dissolving compounds, you are missing a critical element to biofilm disruption.


Discovery #4: Glucoamylase & Amylase

Breaks down biofilm walls & absorbs nutrients which create energy for the body.

Present in saliva, and also secreted by the pancreas, these enzymes serve 2 purposes in Restore 3: To support breakdown of the biofilm barrier by removing the free glucose molecules from biofilm walls, allowing their structures to further break down. And to convert these glucose molecules into immediate, usable energy for the body. Studies [10] have shown glucoamylase may be useful in reducing gas, bloating, heartburn and loss of appetite.[11]



Discovery #5: Lipase

Breaks down leftover fats and carbohydrates in the intestine and bloodstream.

Lipase is an enzyme the body uses to break down fats in food so they can be absorbed in the intestines. Lipase is produced in the pancreas, mouth, and stomach. Lipase isn’t a proteolytic (protein digesting), however it complements the action that the proteolytic enzymes have by working on leftover fats and carbohydrates both in the intestinal tract and the bloodstream — cleaning up what proteolytics cannot touch.

Discovery #6: Bacillus Coagulans

Replenishes the gut microbiome, boosts immunity, improves digestion & targets and eliminates pathogenic bacteria.

Much research has been done on Bacillus coagulans in the past 10 years and several recent studies in particular have indicated B. coagulans to be a powerful catalyst in significantly improving abdominal pain and bloating in people with IBS and other related symptoms [12],[13]. B. coagulans is one of the few probiotics that doesn’t require refrigeration and is able to survive the exposure to the acid and bile it encounters in the GI tract while having the unique ability to rapidly colonize once it reaches the intestinal tract. Most probiotic supplements do not go on to colonize the GI tract.

Discovery #7: Bacillus Subtilis

Suppresses the growth of harmful pathogens, strengthens immunity & enhances the growth of other beneficial probiotic strains.

Bacillus subtilis has long been an important part of the traditional Japanese fermented food, Natto, and the consumption of this has been linked to several health benefits. B. subtilis also exists naturally in a healthy human G.I. tract. Just like B. coagulans, it is an extremely hearty, spore forming probiotic that requires no refrigeration and studies indicate its ability to target and colonize and crowd out [14] pathogenic bacteria in the gut, produce protease and amylase enzymes and stimulate the growth of various lactobacillus species of beneficial probiotics. B. subtilis has also been used as an anti-bacterial and anti-fungal agent in industrial and medical applications [15] and at one point was widely used as a broad spectrum antibiotic, which was lost after less costly methods of producing antibiotics were discovered.


Fun Fact #2


Frequently Asked Questions:

Can’t find the answer to your question below? Feel free to contact us toll free at (888) 627-5170 or by email at support@restore3.com.

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